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It has reported that ATF4 transcriptionally activates serine biosynthetic genes in response to serine starvation in NSCLC cells [20]

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(Yan et al., 2015)

Methods Database of IBD patients at 5 tertiary care IBD centers in India were analyzed retrospectively

They highlight that tumor-generated lactic acid acidifies the microenvironment, which, in the presence of TGF-, fosters Treg development via enhanced lactylation of proteins like moesin that bolster TGF- receptor signaling (155)